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We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
The findings showed that 45.1% of those taking I-3856 reported significant relief from abdominal pain compared to 33.9% in the placebo group. While I-3856 improved quality of life scores, the study did not demonstrate significant changes in bowel movement frequency.
Overall, I-3856 shows promise in alleviating abdominal pain and enhancing quality of life for those suffering from IBS-C.
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The study revealed that treatment with saccharomyces cerevisiae significantly reduced excessive defecation and colonic hypermotility. We noted improvements in the contractile activity of colonic muscles, along with changes in immune responses and gut microbiota diversity.
Overall, saccharomyces cerevisiae showed promise for alleviating symptoms associated with IBS-D by addressing both gut motility and inflammation.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
This probiotic appears to work by inhibiting serotonin-induced contractions, providing insight into its potential effectiveness for those suffering from IBS. However, it didn’t influence contractions caused by acetylcholine, indicating a targeted action on serotonin pathways.
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Frequently Asked Questions
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by a range of symptoms including abdominal pain, bloating, gas, and altered bowel habits, which can manifest as diarrhea, constipation, or a combination of both. The exact cause of IBS isn't fully understood, but it's believed to stem from a complex interplay of factors including gut sensitivity, changes in gut motility, and psychosocial elements such as stress or anxiety. IBS is often classified into different types based on the predominant symptoms, such as IBS with diarrhea (IBS-D), IBS with constipation (IBS-C), and a mixed type (IBS-M).
Managing IBS can be multifaceted, often requiring a tailored approach based on individual symptoms and triggers. Dietary changes are frequently recommended, including low-FODMAP diets, which involve reducing fermentable carbohydrates that can exacerbate symptoms. In addition to dietary adjustments, stress management techniques and medications aimed at addressing specific symptoms, such as anti-diarrheal agents or laxatives, may also be beneficial. Since IBS can significantly impact quality of life, consulting with a healthcare provider or a registered dietitian is essential for developing an effective management plan.
Saccharomyces boulardii is a beneficial yeast strain known for its probiotic properties. Originally isolated from lychee and mangosteen fruit in the 1920s by French microbiologist Henri Boulard, this yeast is widely recognized for its ability to support digestive health. It is commonly used to prevent and treat diarrhea, especially in cases related to antibiotic use or gastrointestinal infections. Saccharomyces boulardii works by helping to maintain the natural balance of good bacteria in the gut, promoting the growth of beneficial microorganisms, and producing substances that inhibit pathogen growth.
In addition to its anti-diarrheal benefits, research suggests that Saccharomyces boulardii may also contribute to other health benefits, including digestive recovery after gastrointestinal illness and potential support for conditions like irritable bowel syndrome (IBS). While it is generally regarded as safe for most individuals, those with compromised immune systems or central venous catheters should consult healthcare professionals prior to use. As always, it's best to choose high-quality supplements that clearly specify the strain and dosage of Saccharomyces boulardii to ensure efficacy.
Saccharomyces boulardii, a specific strain of yeast probiotic, has garnered attention for its potential benefits in managing gastrointestinal issues, including Irritable Bowel Syndrome (IBS). Some studies suggest that this probiotic may contribute to improving the symptoms of IBS, such as bloating, gas, and diarrhea, by restoring the balance of gut microbiota and enhancing the gut barrier function. Its ability to modulate inflammation and provide a protective effect against an imbalanced intestinal environment could make it a valuable addition to the dietary regimen of individuals experiencing IBS.
However, the evidence supporting the efficacy of Saccharomyces boulardii specifically for IBS is still emerging, and results can vary from person to person. It's essential to consult with a healthcare professional before incorporating any new supplement into your routine, especially for managing conditions like IBS. While probiotics like Saccharomyces boulardii might offer some individuals relief, a comprehensive approach that includes dietary adjustments, lifestyle changes, and possibly other treatments may be necessary for optimal management of the syndrome.
Based on user reviews, many individuals taking Saccharomyces boulardii for Irritable Bowel Syndrome (IBS) report noticing improvements within a relatively short timeframe. Some users have indicated that they began to see significant results after just one week of use (Read Review). Others have shared experiences of improvement over a month (Read Review), with notable changes in bowel regularity and symptom management.
Many reviews express that for optimal results, consistent daily intake is crucial. Users who have maintained regular use often describe a gradual but steady improvement in their gut health, with some stating that they began feeling relief from their symptoms after several weeks of ongoing treatment (Read Review). Overall, while experiences may vary, it seems that initial positive changes can generally be observed within a week, with more significant improvements following regular use over a month.
Recent scientific studies indicate that the probiotic Saccharomyces boulardii may offer some promise for managing symptoms associated with Irritable Bowel Syndrome (IBS). Research has shown that S. boulardii can influence gut motility and potentially alleviate symptoms of diarrhea-predominant IBS, particularly in cases related to bacterial overgrowth. In one randomized study, participants taking S. boulardii demonstrated a greater reduction in bacterial overgrowth and digestive distress compared to those receiving standard dietary advice alone [2]. Additionally, a study found that administering S. boulardii resulted in significant improvements in gut motility and reduced inflammation in mouse models of IBS [6].
However, while S. boulardii appears to positively affect gut health and microbiota, its overall effectiveness for IBS symptom relief remains inconclusive. Some trials reported no substantial benefits for IBS patients, suggesting that additional research is needed to establish more definitive conclusions regarding its efficacy [9]. Overall, while early findings are encouraging, patients should consult healthcare providers for personalized advice and consider that S. boulardii might not be the solution for every IBS sufferer.
Based on user reviews, many individuals have reported substantial improvements in their symptoms after incorporating Saccharomyces boulardii into their routines. Several users have noted significant enhancements in digestion and regularity, particularly those dealing with irritable bowel syndrome (IBS), with reports of reduced diarrhoea and better-managed symptoms (Read Review). One user mentioned that after a year of suffering from gas-type IBS, the supplement had effectively alleviated their symptoms, allowing for a more normalized lifestyle (Read Review).
Others have experienced positive changes when using the product during and after antibiotic treatments, indicating its role in maintaining gut health and managing potential side effects such as diarrhoea (Read Review). Users have described varying degrees of success; while some report improvements within a week (Read Review), others have observed notable changes over a month of consistent use (Read Review). Overall, while individual experiences may differ, many users have appreciated the beneficial effects of this probiotic yeast on their digestive health.
Based on user reviews, there is a consensus among many individuals that combining Saccharomyces boulardii with other supplements can be beneficial for managing Irritable Bowel Syndrome (IBS). Several users have reported significant improvements in their symptoms, specifically highlighting the ability of this probiotic yeast to work in tandem with antibiotics to maintain gut health and combat the side effects often associated with such treatments (Read Review). This synergistic effect appears to enhance overall digestive function while also reducing symptoms like diarrhoea and gas (Read Review).
Furthermore, reviews suggest that the use of Saccharomyces boulardii in combination with other probiotics may yield even better results, as it is noted for its unique properties that differentiate it from traditional bacterial probiotics (Read Review). Users often recommend it as a safe alternative, particularly after the use of antibiotics, which can compromise gut flora (Read Review). The general consensus is that while individual experiences may vary, combining this supplement with others can enhance its efficacy in providing relief from IBS symptoms.
Based on user reviews, it appears that there is no specific consensus on the exact right dose of Saccharomyces Boulardii for treating Irritable Bowel Syndrome (IBS). However, many users have reported positive experiences with regular use of the product, typically suggesting a daily intake to help manage symptoms. For instance, one user mentioned that taking two capsules at night ensured a bowel movement the next day and highly recommended this approach (Read Review). Another review highlighted the product's effectiveness in balancing intestinal flora, noting significant improvements in the user's IBS symptoms with ongoing use (Read Review).
Users also shared experiences indicating that maintaining consistent intake of Saccharomyces Boulardii, whether through daily doses or during antibiotic treatments, led to better gut health and symptom relief from IBS (Read Review). Although the specific dosages weren't detailed, the general feedback emphasizes the importance of regular consumption for optimal results in alleviating IBS symptoms.
Those taking the probiotic showed a greater decrease in bacterial overgrowth and better improvement in digestive symptoms. Specifically, the reduction in digestive distress was more pronounced, and the friendly bacteria F. prausnitzii increased among these patients. Our findings suggest that further exploration of this promising probiotic is warranted.
After careful evaluation of symptoms and quality of life before, during, and after treatment, we found no significant differences between the two groups. This suggests that saccharomyces boulardii didn’t provide any real benefits for patients suffering from diarrhea-predominant IBS.
References
- Girard P, Verleye M, Castagné V. Serotoninergic Mechanisms of Action in the Relaxant Properties of Saccharomyces boulardii CNCM I-745 on the Intestine. Dig Dis Sci. 2025;70:191. doi:10.1007/s10620-024-08786-y
- Bustos Fernández LM, Man F, Lasa JS. Impact of Saccharomyces boulardii CNCM I-745 on Bacterial Overgrowth and Composition of Intestinal Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome Patients: Results of a Randomized Pilot Study. Dig Dis. 2023;41:798. doi:10.1159/000528954
- Gu Y, Wang C, Qin X, Zhou B, Liu X, et al. Saccharomyces boulardii, a yeast probiotic, inhibits gut motility through upregulating intestinal serotonin transporter and modulating gut microbiota. Pharmacol Res. 2022;181:106291. doi:10.1016/j.phrs.2022.106291
- Constante M, De Palma G, Lu J, Jury J, Rondeau L, et al. Saccharomyces boulardii CNCM I-745 modulates the microbiota-gut-brain axis in a humanized mouse model of Irritable Bowel Syndrome. Neurogastroenterol Motil. 2021;33:e13985. doi:10.1111/nmo.13985
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. doi:10.1007/s12602-018-9401-3
- Brun P, Scarpa M, Marchiori C, Sarasin G, Caputi V, et al. Saccharomyces boulardii CNCM I-745 supplementation reduces gastrointestinal dysfunction in an animal model of IBS. PLoS One. 2017;12:e0181863. doi:10.1371/journal.pone.0181863
- Abbas Z, Yakoob J, Jafri W, Ahmad Z, Azam Z, et al. Cytokine and clinical response to Saccharomyces boulardii therapy in diarrhea-dominant irritable bowel syndrome: a randomized trial. Eur J Gastroenterol Hepatol. 2014;26:630. doi:10.1097/MEG.0000000000000094
- Bafutto M, Almeida JR, Leite NV, Costa MB, Oliveira EC, et al. Treatment of diarrhea-predominant irritable bowel syndrome with mesalazine and/or Saccharomyces boulardii. Arq Gastroenterol. 2013;50:304. doi:10.1590/S0004-28032013000400012
- Kabir MA, Ishaque SM, Ali MS, Mahmuduzzaman M, Hasan M. Role of Saccharomyces boulardii in diarrhea predominant irritable bowel syndrome. Mymensingh Med J. 2011;20:397.
- Choi CH, Jo SY, Park HJ, Chang SK, Byeon JS, et al. A randomized, double-blind, placebo-controlled multicenter trial of saccharomyces boulardii in irritable bowel syndrome: effect on quality of life. J Clin Gastroenterol. 2011;45:679. doi:10.1097/MCG.0b013e318204593e
- McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010;16:2202.
- Siyal M, Abbas Z, Amir MR, Qadeer MA. Saccharomyces cerevisiae for abdominal pain and discomfort in irritable bowel syndrome patients. Pak J Med Sci. 2024;40:492. doi:10.12669/pjms.40.3.8349
- Liu J, Ren H, Yuan F, Shao M, Luo H. The effects of on rat colonic hypermotility induced by repeated water avoidance stress and the potential mechanism. PeerJ. 2022;10:e14390. doi:10.7717/peerj.14390
- Mourey F, Decherf A, Jeanne JF, Clément-Ziza M, Grisoni ML, et al. I-3856 in irritable bowel syndrome with predominant constipation. World J Gastroenterol. 2022;28:2509. doi:10.3748/wjg.v28.i22.2509
- Gayathri R, Aruna T, Malar S, Shilpa B, Dhanasekar KR. Efficacy of Saccharomyces cerevisiae CNCM I-3856 as an add-on therapy for irritable bowel syndrome. Int J Colorectal Dis. 2020;35:139. doi:10.1007/s00384-019-03462-4
- Cayzeele-Decherf A, Pélerin F, Leuillet S, Douillard B, Housez B, et al. CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis. World J Gastroenterol. 2017;23:336. doi:10.3748/wjg.v23.i2.336
- Spiller R, Pélerin F, Cayzeele Decherf A, Maudet C, Housez B, et al. Randomized double blind placebo-controlled trial of Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: improvement in abdominal pain and bloating in those with predominant constipation. United European Gastroenterol J. 2016;4:353. doi:10.1177/2050640615602571
- Pineton de Chambrun G, Neut C, Chau A, Cazaubiel M, Pelerin F, et al. A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome. Dig Liver Dis. 2015;47:119. doi:10.1016/j.dld.2014.11.007
