Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.4
USERS' SCORE
Moderately Good
Based on 127 Reviews
7.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Saccharomyces boulardii(an S. cerevisiae Strain)
250 mg(5 Billion CFU)
†
MOS Yeast Fraction(Min. 35% Manno-oligosaccharides [MOS]) (S. cerevisiae)
200 mg
†
Top Medical Research Studies
9.5
We explored how Saccharomyces cerevisiae affects patients with irritable bowel syndrome (IBS). In a study involving thirty participants, we administered 500 mg capsules of this yeast twice daily for four weeks. Weekly evaluations showed significant improvements in abdominal pain and general quality of life, with notable reductions in pain scores and enhancements in various aspects of daily living. This suggests Saccharomyces cerevisiae could be a valuable treatment option for alleviating IBS symptoms.
Read More
9
We conducted a study to assess the effectiveness of Saccharomyces cerevisiae CNCM I-3856 in treating irritable bowel syndrome (IBS). Using a randomized, placebo-controlled design, 100 newly diagnosed IBS patients received either the yeast or a placebo alongside standard treatment for 8 weeks.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
Read More
8
We explored the impact of the probiotic I-3856 on managing irritable bowel syndrome with predominant constipation (IBS-C) through a thorough eight-week randomized, double-blind study involving 456 participants.
The findings showed that 45.1% of those taking I-3856 reported significant relief from abdominal pain compared to 33.9% in the placebo group. While I-3856 improved quality of life scores, the study did not demonstrate significant changes in bowel movement frequency.
Overall, I-3856 shows promise in alleviating abdominal pain and enhancing quality of life for those suffering from IBS-C.
The findings showed that 45.1% of those taking I-3856 reported significant relief from abdominal pain compared to 33.9% in the placebo group. While I-3856 improved quality of life scores, the study did not demonstrate significant changes in bowel movement frequency.
Overall, I-3856 shows promise in alleviating abdominal pain and enhancing quality of life for those suffering from IBS-C.
Read More
Most Useful Reviews
9
Effective alternative
218 people found this helpful
Jarrow Formulas saccharomycetes do not settle in the intestines but pass through the gastrointestinal tract unscathed, offering a healing effect. It effectively treats acne, diarrhoea, irritable bowel syndrome, and enhances nutrient absorption. Completely safe, I take it with me on journeys instead of bacterial probiotics. Highly recommended!
Read More
9
Symptoms largely reversed
65 people found this helpful
Saccharomyces Success! About seven years ago, I had an ulceration in my lower colon and ended up hospitalised for it haemorrhaging. Mega doses of antibiotics were used in treatment, without any confirmed diagnosis of a bacterial infection. After battling gastrointestinal issues for years, I had nearly accepted a life of symptomatic IBS/IBD, enduring countless trips to the bathroom daily. I researched extensively and identified iron overload and a devastated gut flora as culprits. I donated blood and began taking Jarrow Formulas Saccharomyces Boulardii, alongside a high-quality probiotic. I’m pleased to say that virtually all my IBS symptoms have been largely reversed. I'm unsure if it is due to the blood donation, the Saccharomyces Boulardii, or both, but I plan to monitor my iron levels and maintain my probiotic regimen.
Read More
9
Effective interaction
33 people found this helpful
S. boulardi is not a typical probiotic; it is a yeast-like fungus that travels through the intestines, helping to curb pathogenic growth and restore normal flora. Its use is beneficial during antibiotic treatment and for those suffering from irritable bowel syndrome.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.4
- All Researches
9.5
We explored how Saccharomyces cerevisiae affects patients with irritable bowel syndrome (IBS). In a study involving thirty participants, we administered 500 mg capsules of this yeast twice daily for four weeks. Weekly evaluations showed significant improvements in abdominal pain and general quality of life, with notable reductions in pain scores and enhancements in various aspects of daily living. This suggests Saccharomyces cerevisiae could be a valuable treatment option for alleviating IBS symptoms.
Read More
9
We explored how Saccharomyces boulardii CNCM I-745 influences gastrointestinal issues related to irritable bowel syndrome (IBS) using a mouse model. By inoculating mice with Herpes Simplex Virus type 1 to simulate IBS symptoms, we found that the probiotic improved gut motility and reduced inflammation. After four weeks of treatment, the probiotic not only enhanced intestinal movement but also restored nerve structure integrity and decreased harmful cytokine levels. Overall, Saccharomyces boulardii shows promise in addressing IBS-like symptoms in our animal study.
Read More
9
We investigated how saccharomyces cerevisiae affects gut motility in rats undergoing repeated water avoidance stress, simulating diarrhea-predominant irritable bowel syndrome.
The study revealed that treatment with saccharomyces cerevisiae significantly reduced excessive defecation and colonic hypermotility. We noted improvements in the contractile activity of colonic muscles, along with changes in immune responses and gut microbiota diversity.
Overall, saccharomyces cerevisiae showed promise for alleviating symptoms associated with IBS-D by addressing both gut motility and inflammation.
The study revealed that treatment with saccharomyces cerevisiae significantly reduced excessive defecation and colonic hypermotility. We noted improvements in the contractile activity of colonic muscles, along with changes in immune responses and gut microbiota diversity.
Overall, saccharomyces cerevisiae showed promise for alleviating symptoms associated with IBS-D by addressing both gut motility and inflammation.
Read More
9
We conducted a study to assess the effectiveness of Saccharomyces cerevisiae CNCM I-3856 in treating irritable bowel syndrome (IBS). Using a randomized, placebo-controlled design, 100 newly diagnosed IBS patients received either the yeast or a placebo alongside standard treatment for 8 weeks.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
Read More
8
We explored how Saccharomyces boulardii CNCM I-745 impacts intestinal motility, particularly in the context of irritable bowel syndrome (IBS) with diarrhea. Using isolated rat ileum, we observed that S. boulardii can significantly reduce contractions induced by serotonin, suggesting it helps to regulate bowel movements.
This probiotic appears to work by inhibiting serotonin-induced contractions, providing insight into its potential effectiveness for those suffering from IBS. However, it didn’t influence contractions caused by acetylcholine, indicating a targeted action on serotonin pathways.
This probiotic appears to work by inhibiting serotonin-induced contractions, providing insight into its potential effectiveness for those suffering from IBS. However, it didn’t influence contractions caused by acetylcholine, indicating a targeted action on serotonin pathways.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 127 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective alternative
218 people found this helpful
Jarrow Formulas saccharomycetes do not settle in the intestines but pass through the gastrointestinal tract unscathed, offering a healing effect. It effectively treats acne, diarrhoea, irritable bowel syndrome, and enhances nutrient absorption. Completely safe, I take it with me on journeys instead of bacterial probiotics. Highly recommended!
Read More
9
Symptoms largely reversed
65 people found this helpful
Saccharomyces Success! About seven years ago, I had an ulceration in my lower colon and ended up hospitalised for it haemorrhaging. Mega doses of antibiotics were used in treatment, without any confirmed diagnosis of a bacterial infection. After battling gastrointestinal issues for years, I had nearly accepted a life of symptomatic IBS/IBD, enduring countless trips to the bathroom daily. I researched extensively and identified iron overload and a devastated gut flora as culprits. I donated blood and began taking Jarrow Formulas Saccharomyces Boulardii, alongside a high-quality probiotic. I’m pleased to say that virtually all my IBS symptoms have been largely reversed. I'm unsure if it is due to the blood donation, the Saccharomyces Boulardii, or both, but I plan to monitor my iron levels and maintain my probiotic regimen.
Read More
9
Effective interaction
33 people found this helpful
S. boulardi is not a typical probiotic; it is a yeast-like fungus that travels through the intestines, helping to curb pathogenic growth and restore normal flora. Its use is beneficial during antibiotic treatment and for those suffering from irritable bowel syndrome.
Read More
9
Digestive improvement
33 people found this helpful
After suffering from rotavirus, I began taking boulardii, which significantly improved my digestion and bowel function. It's also crucial during antibiotic use, as it maintains gut health and supports overall immunity. Highly effective and safe; I always keep a jar on hand.
Read More
9
Intestinal restoration
24 people found this helpful
This product successfully restored my intestines in just a month. After suffering from dysbiosis following antibiotics, I now recommend it for bowel recovery. Taking it daily has made a significant difference in my health overall. If you find this helpful, please give a like!
Read More
Frequently Asked Questions
9
Improved bowel movements
13 people found this helpful
Excellent! As a Crohn's patient suffering from diarrhoea year-round, I decided to try Saccharomyces boulardii. After just a week, my bowel movements began to form properly. It has notably improved my gut health, and I will definitely repurchase.
9
Intestinal restoration
24 people found this helpful
This product successfully restored my intestines in just a month. After suffering from dysbiosis following antibiotics, I now recommend it for bowel recovery. Taking it daily has made a significant difference in my health overall. If you find this helpful, please give a like!
9
Significant effect
19 people found this helpful
After 20 years of irritable bowel syndrome, I found Bouladi. It remarkably lessened my symptoms, allowing me to manage my bolus without the usual urgency. This product has made a significant difference in my quality of life, providing a more relaxed experience.
9
Effective IBS treatment
2 people found this helpful
After two years of struggling with gas-type irritable bowel syndrome and seeing no progress, I began taking this medication. It has indeed worked for me, allowing me to stop visiting the hospital while achieving consistent results.
9
Digestive improvement
33 people found this helpful
After suffering from rotavirus, I began taking boulardii, which significantly improved my digestion and bowel function. It's also crucial during antibiotic use, as it maintains gut health and supports overall immunity. Highly effective and safe; I always keep a jar on hand.
9
Effective interaction
33 people found this helpful
S. boulardi is not a typical probiotic; it is a yeast-like fungus that travels through the intestines, helping to curb pathogenic growth and restore normal flora. Its use is beneficial during antibiotic treatment and for those suffering from irritable bowel syndrome.
9
Supports digestion
6 people found this helpful
Saccharomycetes boulardi is a fantastic probiotic for excellent intestinal function. It’s recommended for acute diarrhoea, skin issues, irritable bowel syndrome, and even Crohn's disease, as it reduces spasms, swelling, and pain. It’s also beneficial after antibiotic use.
8.5
Effective bowel movement
2 people found this helpful
This product has worked wonders for my bowel movements. I find it excellent at eliminating bad bacteria in the intestines and promoting good bacteria. Taking two at night ensures a bowel movement the next day. Highly recommended!
7.5
Balanced gut flora
2 people found this helpful
My son has irritable bowel syndrome, and this probiotic has significantly improved his condition by balancing intestinal flora and reducing diarrhoea episodes. I highly recommend it.
7
Saccharomyces boulardii aids IBS-D
We assessed how Saccharomyces boulardii CNCM I-745 affects patients with diarrhea-predominant irritable bowel syndrome (IBS-D) linked to small intestinal bacterial overgrowth (SIBO). In our study, patients received either the probiotic with dietary advice or just dietary advice for 15 days.
Those taking the probiotic showed a greater decrease in bacterial overgrowth and better improvement in digestive symptoms. Specifically, the reduction in digestive distress was more pronounced, and the friendly bacteria F. prausnitzii increased among these patients. Our findings suggest that further exploration of this promising probiotic is warranted.
Those taking the probiotic showed a greater decrease in bacterial overgrowth and better improvement in digestive symptoms. Specifically, the reduction in digestive distress was more pronounced, and the friendly bacteria F. prausnitzii increased among these patients. Our findings suggest that further exploration of this promising probiotic is warranted.
9
We explored how Saccharomyces boulardii CNCM I-745 influences gastrointestinal issues related to irritable bowel syndrome (IBS) using a mouse model. By inoculating mice with Herpes Simplex Virus type 1 to simulate IBS symptoms, we found that the probiotic improved gut motility and reduced inflammation. After four weeks of treatment, the probiotic not only enhanced intestinal movement but also restored nerve structure integrity and decreased harmful cytokine levels. Overall, Saccharomyces boulardii shows promise in addressing IBS-like symptoms in our animal study.
0
We conducted a randomized double-blind placebo-controlled trial to understand the effects of saccharomyces boulardii on diarrhea-predominant irritable bowel syndrome (IBS). In our study, thirty-five patients received either the probiotic or a placebo for a month.
After careful evaluation of symptoms and quality of life before, during, and after treatment, we found no significant differences between the two groups. This suggests that saccharomyces boulardii didn’t provide any real benefits for patients suffering from diarrhea-predominant IBS.
After careful evaluation of symptoms and quality of life before, during, and after treatment, we found no significant differences between the two groups. This suggests that saccharomyces boulardii didn’t provide any real benefits for patients suffering from diarrhea-predominant IBS.
References
- Girard P, Verleye M, Castagné V. Serotoninergic Mechanisms of Action in the Relaxant Properties of Saccharomyces boulardii CNCM I-745 on the Intestine. Dig Dis Sci. 2025;70:191. 10.1007/s10620-024-08786-y
- Bustos Fernández LM, Man F, Lasa JS. Impact of Saccharomyces boulardii CNCM I-745 on Bacterial Overgrowth and Composition of Intestinal Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome Patients: Results of a Randomized Pilot Study. Dig Dis. 2023;41:798. 10.1159/000528954
- Gu Y, Wang C, Qin X, Zhou B, Liu X, et al. Saccharomyces boulardii, a yeast probiotic, inhibits gut motility through upregulating intestinal serotonin transporter and modulating gut microbiota. Pharmacol Res. 2022;181:106291. 10.1016/j.phrs.2022.106291
- Constante M, De Palma G, Lu J, Jury J, Rondeau L, et al. Saccharomyces boulardii CNCM I-745 modulates the microbiota-gut-brain axis in a humanized mouse model of Irritable Bowel Syndrome. Neurogastroenterol Motil. 2021;33:e13985. 10.1111/nmo.13985
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. 10.1007/s12602-018-9401-3
- Brun P, Scarpa M, Marchiori C, Sarasin G, Caputi V, et al. Saccharomyces boulardii CNCM I-745 supplementation reduces gastrointestinal dysfunction in an animal model of IBS. PLoS One. 2017;12:e0181863. 10.1371/journal.pone.0181863
- Abbas Z, Yakoob J, Jafri W, Ahmad Z, Azam Z, et al. Cytokine and clinical response to Saccharomyces boulardii therapy in diarrhea-dominant irritable bowel syndrome: a randomized trial. Eur J Gastroenterol Hepatol. 2014;26:630. 10.1097/MEG.0000000000000094
- Bafutto M, Almeida JR, Leite NV, Costa MB, Oliveira EC, et al. Treatment of diarrhea-predominant irritable bowel syndrome with mesalazine and/or Saccharomyces boulardii. Arq Gastroenterol. 2013;50:304. 10.1590/S0004-28032013000400012
- Kabir MA, Ishaque SM, Ali MS, Mahmuduzzaman M, Hasan M. Role of Saccharomyces boulardii in diarrhea predominant irritable bowel syndrome. Mymensingh Med J. 2011;20:397.
- Choi CH, Jo SY, Park HJ, Chang SK, Byeon JS, et al. A randomized, double-blind, placebo-controlled multicenter trial of saccharomyces boulardii in irritable bowel syndrome: effect on quality of life. J Clin Gastroenterol. 2011;45:679. 10.1097/MCG.0b013e318204593e
- McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010;16:2202.
- Siyal M, Abbas Z, Amir MR, Qadeer MA. Saccharomyces cerevisiae for abdominal pain and discomfort in irritable bowel syndrome patients. Pak J Med Sci. 2024;40:492. 10.12669/pjms.40.3.8349
- Liu J, Ren H, Yuan F, Shao M, Luo H. The effects of on rat colonic hypermotility induced by repeated water avoidance stress and the potential mechanism. PeerJ. 2022;10:e14390. 10.7717/peerj.14390
- Mourey F, Decherf A, Jeanne JF, Clément-Ziza M, Grisoni ML, et al. I-3856 in irritable bowel syndrome with predominant constipation. World J Gastroenterol. 2022;28:2509. 10.3748/wjg.v28.i22.2509
- Gayathri R, Aruna T, Malar S, Shilpa B, Dhanasekar KR. Efficacy of Saccharomyces cerevisiae CNCM I-3856 as an add-on therapy for irritable bowel syndrome. Int J Colorectal Dis. 2020;35:139. 10.1007/s00384-019-03462-4
- Cayzeele-Decherf A, Pélerin F, Leuillet S, Douillard B, Housez B, et al. CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis. World J Gastroenterol. 2017;23:336. 10.3748/wjg.v23.i2.336
- Spiller R, Pélerin F, Cayzeele Decherf A, Maudet C, Housez B, et al. Randomized double blind placebo-controlled trial of Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: improvement in abdominal pain and bloating in those with predominant constipation. United European Gastroenterol J. 2016;4:353. 10.1177/2050640615602571
- Pineton de Chambrun G, Neut C, Chau A, Cazaubiel M, Pelerin F, et al. A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome. Dig Liver Dis. 2015;47:119. 10.1016/j.dld.2014.11.007
